Canada’s Drug Agency, in collaboration with Choosing Wisely Canada and supported by the Appropriate Use Coalition, hosted a multidisciplinary panel of experts to develop evidence-informed consensus statements on a target for long-term care (LTC) homes in Canada, and an annual improvement goal, for the quality indicator “potentially inappropriate use of antipsychotics in long-term care.” These consensus statements are intended to serve as a reference guide for coalition initiatives to improve safety and quality of care by reducing potentially inappropriate antipsychotic use in LTC homes.