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Reimbursement Review

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Title Brand Name Generic Name Files Therapeutic Area Recommendation Type Status Submission Date Recommendation Date Project Number
Anaplastic Lymphoma Kinase (AL...
Final Report
 Anaplastic Lymphoma Kinase (ALK) -Positive Non-small Cell Lung Cancer (NSCLC) Complete PH0058-000
amivantamab Rybrevant amivantamab
Recommendation and Reason Patient and Clinician Group input
 Locally advanced or metastatic non-small cell lung cancer (NSCLC) Reimburse with clinical criteria and/or conditions Active PC0376-000
erdafitinib Balversa erdafitinib
Recommendation and Reason Patient and Clinician Group input
 locally advanced unresectable or metastatic urothelial carcinoma (UC) Reimburse with clinical criteria and/or conditions Active PC0375-000
momelotinib Ojjaara momelotinib
Recommendation and ReasonsPatient and Clinician Group input
 Myelofibrosis Reimburse with clinical criteria and/or conditions Active PC0355-000
ravulizumab Ultomiris ravulizumab
Recommendation and Reason Patient and Clinician Group input
 Generalized Myasthenia Gravis Reimburse with clinical criteria and/or conditions Active SR0855-000
spesolimab Spevigo spesolimab
Recommendation and ReasonsPatient and Clinician Group inputClinical and Pharmacoeconomic Combined ReportFeedback on Draft Recommendation
 generalized pustular psoriasis (GPP) Reimburse with clinical criteria and/or conditions Complete SR0844-000
ferric carboxymaltose Ferinject ferric carboxymaltose
Recommendation and ReasonsClinical and Pharmacoeconomic Combined ReportFeedback on Draft RecommendationPatient and Clinican Group Input
Iron deficiency anemia Reimburse with clinical criteria and/or conditions Complete SR0842-000
exagamglogene autotemcel Casgevy exagamglogene autotemcel
Recommendation and ReasonsPatient and Clinician Group Input
 Transfusion-dependent β-thalassemia Reimburse with clinical criteria and/or conditions Active SG0831-000
exagamglogene autotemcel Casgevy exagamglogene autotemcel
Recommendation and ReasonsClinical and Pharmacoeconomic Combined ReportFeedback on Draft RecommendationPatient and Clinician Group Input
 Sickle cell disease (SCD) Reimburse with clinical criteria and/or conditions Complete SG0830-000
HR positive, HER2 negative bre...
Final Report
 HR positive, HER2 negative breast cancer Complete PH0053-000
Non-small cell lung cancer (NS...
Final Report
 Non-small cell lung cancer (NSCLC) with activating epidermal growth factor receptor (EGFR) mutation Complete PH0054-000
Advanced or metastatic gastric...
Final Report
 Gastric Cancer Complete PH0051-000
everolimus N/A everolimus
Recommendation and ReasonsResponses to the Questions From the Drug ProgramsClinical and Pharmacoeconomic Combined ReportStakeholder Feedback on Draft RecommendationPatient, Clinician and Industry Group Input
 Tuberous Sclerosis Complex (TSC) Reimburse with clinical criteria and/or conditions Complete SX0836-000
enfortumab vedotin Padcev enfortumab vedotin
Recommendation and ReasonsPatient and Clinician Group InputClinical and Pharmacoeconomic Combined ReportFeedback on Draft Recommendation
 Metastatic urothelial cancer Reimburse with clinical criteria and/or conditions Complete PC0353-000
venetoclax Venclexta venetoclax
Recommendation and ReasonsPatient and Clinician Group inputClinical and Pharmacoeconomic Combined ReportFeedback on Draft Recommendation
 Chronic lymphocytic leukemia (CLL) Reimburse with clinical criteria and/or conditions Complete PC0362-000
lisocabtagene maraleucel Breyanzi lisocabtagene maraleucel
Recommendation and ReasonsClinical and Pharmacoeconomic Combined ReportFeedback on Draft RecommendationPatient and Clinician Group input
 Relapsed or refractory large B-cell lymphoma Reimburse with clinical criteria and/or conditions Complete PG0358-000
fruquintinib Fruzaqla fruquintinib
Recommendation and Reason Patient and Clinician Group inputClinical and Pharmacoeconomic Combined ReportFeedback on Draft Recommendation
 Metastatic colorectal cancer (mCRC) Reimburse with clinical criteria and/or conditions Complete PC0352-000
Enzalutamide N/A Enzalutamide
Recommendation and ReasonsResponses to the Questions From the Drug ProgramsClinical and Pharmacoeconomic Combined ReportPatient, Clinician and Industry Group InputFeedback on Draft Recommendation
 Genito-urinary cancer (prostate cancer) Reimburse with clinical criteria and/or conditions Complete PX0366-000
Mepolizumab N/A Mepolizumab
Recommendation and ReasonsResponses to the Questions From the Drug Programs Clinical and Pharmacoeconomic Combined ReportPatient and Clinician Group InputFeedback on Draft Recommendation
 Eosinophilic Granulomatosis with Polyangiitis Reimburse with clinical criteria and/or conditions Complete SX0839-000
Adult Classical Hodgkin Lympho...
Final Report
Adult Classical Hodgkin Lymphoma Complete PH0052-000
ciltacabtagene autoleucel Carvykti ciltacabtagene autoleucel
Recommendation and ReasonsClinical, Pharmacoeconomic and Ethics Combined ReportFeedback on Draft RecommendationPatient and Clinician Group input
 Relapsed or refractory multiple myeloma Reimburse with clinical criteria and/or conditions Complete PG0361-000
avapritinib Ayvakyt avapritinib
Recommendation and ReasonsPatient and Clinician Group inputClinical and Pharmacoeconomic Combined ReportFeedback on Draft Recommendation
 Advanced Systemic Mastocytosis Reimburse with clinical criteria and/or conditions Complete PC0335-000
alectinib Alecensaro alectinib
Recommendation and Reason Patient, Clinician and Industry Group InputClinical and Pharmacoeconomic Combined ReportFeedback on Draft Recommendation
 ALK-positive NSCLC Reimburse with clinical criteria and/or conditions Complete PC0350-000
sotatercept Winrevair sotatercept
Recommendation and ReasonsPatient and Clinician Group InputClinical and Pharmacoeconomic Combined ReportFeedback on Draft Recommendation
 Pulmonary arterial hypertension (WHO group 1) Reimburse with clinical criteria and/or conditions Complete SR0828-000
eplontersen Wainua eplontersen
Recommendation and ReasonsPatient and Clinician Group InputClinical and Pharmacoeconomic Combined ReportFeedback on Draft Recommendation
 Polyneuropathy in hereditary transthyretin-mediated amyloidosis Reimburse with clinical criteria and/or conditions Complete SR0826-000

Health Technology Review

Last Updated
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Title Description Files Last Updated Project Sub Line Status Project Number
Subtalar Joint Arthroereisis
Subtalar Joint Arthroereisis
Rapid Review Completed RC1568-000
Association Between Opioid Use and the Development of Diverticulitis
Association Between Opioid Use and the Development of DiverticulitisSummary ReportFinal Project Protocol
 Observational Study Completed OS0001-000
High Dose Bupropion for Depression
High Dose Bupropion for Depression
Rapid Review Completed RC1564-000
Health System Readiness for Disease-Modifying Therapies for Alzheimer's Disease
Final ReportSummary Report
 Active CM0003-000
Utilization of Drugs in Patients With Major Neurocognitive Disorder
Technology Review In Progress HC0099-000
Trends in hydromorphone prescribing in Canada from 2018 to 2024
Technology Review In Progress HC0096-000
Virtual Mental Health Counselling
Virtual Mental Health Counselling
Rapid Review Completed RC1569-000
Methadone for Surgical Patients
Methadone for Surgical Patients
Rapid Review Completed RC1565-000
Antiviral Drugs for the Treatment of Suspected or Confirmed Influenza A or Influenza B
Systematic Review In Progress RE0052-000
Icatibant Implementation Advice Panel
Implementation Advice for Icatibant
 Technology Review Completed HC0097-000 - SX0849-000
Use of Oral Fluoroquinolones in Canada: Drug Utilization Study Update
ReportProtocolSummary Report
 Technology Review Complete HC0073-000
Artificial Intelligence–Assisted Colonoscopy for Detecting Polyps, Adenomas, Precancerous Lesions, and Colorectal Cancer
Artificial Intelligence–Assisted Colonoscopy for Detecting Polyps, Adenomas, Pr…
 Rapid Review Completed RC1559-000
RapidAI for Stroke Detection
Final RecommendationRapidAI for Stroke Detection: Main ReportSupporting Information for RapidAI ReviewSupporting Information for AI Implementation Review
 Optimal Use Active OP0556-000
Attention-Deficit/Hyperactivity Disorder Medications for Adults
Attention-Deficit/Hyperactivity Disorder Medications for Adults
Rapid Review Completed RC1556-000
Overview of Systematic Reviews of Immune Checkpoint Inhibitors in Non–Small-Cell Lung Cancer with EGFR, ALK, ROS1, and RET Actionable Driver Mutations
Summary ReportFinal ReportProtocol - Final
Systematic Review Completed RE0050-000
Utilization of Cancer Therapies for Advanced Non–Small Cell Lung Cancer With an Oncogenic Driver Mutation
Summary ReportUtilization of Cancer Therapies for Advanced Non–Small Cell Lung Cancer With an…Final Project Protocol
 Technology Review Completed HC0084-OS0008
Benchmarking CT and MRI exams
In Progress CM0016-000
Optimal Wait Times
In Progress CM0014-000
Long-Acting Inhaled Drugs for Chronic Obstructive Pulmonary Disease
Therapeutic Review Active TR0016-000
Federal, Provincial, and Territorial Coverage of Diagnostic Sleep Studies
Environmental Scan Completed ES0382-000
Midazolam Compared With Lorazepam in Adults to Control Seizures
Midazolam Compared With Lorazepam in Adults to Control Seizures
Rapid Review Completed RC1554-000
Utilization of Long-Acting Injectable Antipsychotics
Technology Review In Progress HC0098-000
Review of Guidelines on Bupropion for Depression
Review of Guidelines on Bupropion for Depression
Rapid Review Completed RC1558-000
GLP-1 Receptor Agonists and Self-Harm
Observational Study Active OS0009-000
Gabapentin for Seizures
Gabapentin for Seizures
Rapid Review Completed RC1557-000

Horizon Scan

Last Updated
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Title Description Files Last Updated Project Sub Line Status Project Number
Facial Analysis Technology for Pain Detection
Facial Analysis Technology for Pain Detection
Health Technology Update Completed EN0047-000
An Overview of Clinical Applications of Virtual and Augmented Reality
An Overview of Clinical Applications of Virtual and Augmented Reality
Emerging Health Technologies Completed EH0111-000
Xylazine Test Strips for Drug Checking
Xylazine Test Strips for Drug Checking
 Health Technology Update Completed EN0049-000
Hearing Aids and Dementia
Hearing Aids and Dementia
Emerging Health Technologies Completed EH0120-000
Rapid HIV Self-Testing
Rapid HIV Self-Testing
 Emerging Health Technologies Completed EH0118-000
Hybrid Operating Rooms Suites
Hybrid Operating Rooms Suites
Emerging Health Technologies Completed EH0121-000
An Overview of Pharmacogenomic Testing for Psychiatric Disorders
An Overview of Pharmacogenomic Testing for Psychiatric Disorders
Emerging Health Technologies Completed EH0115-000
Cognitive Health Assessment Management Platform
Cognitive Health Assessment Management Platform
Health Technology Update Completed EN0046-000
Reducing the Environmental Impact of Clinical Care
Reducing the Environmental Impact of Clinical Care
Completed EH0112-000
Laser Treatment for Lower Back Pain
Laser Treatment for Lower Back Pain
Health Technology Update Completed EN0044-000
Point-of-Care Tests for Pancreatitis
Point-of-Care Tests for Pancreatitis
 Health Technology Update Completed EN0045-000
Wastewater Surveillance for Communicable Disease
Wastewater Surveillance for Communicable Disease
 Emerging Health Technologies Completed EH0114-000
Robotic Surgical Systems for Orthopedics
Robotic Surgical Systems for Orthopedics
 Emerging Health Technologies Completed EH0108-000
Rapid Syphilis Testing
Rapid Syphilis Testing
 Health Technology Update Completed EN0043-000
Vagus Nerve Stimulation for the Treatment of Post–COVID-19 Condition
Vagus Nerve Stimulation for the Treatment of Post–COVID-19 Condition
 Health Technology Update Active EN0040-000
An Overview of Comprehensive Genomic Profiling Technologies to Inform Cancer Care
An Overview of Comprehensive Genomic Profiling Technologies to Inform Cancer Ca…
 Emerging Health Technologies Completed EH0106-000
Understanding the Portrait of Dementia Care in Canada: Our Panel of Experts
Understanding the Portrait of Dementia Care in Canada: Our Panel of Experts
 Emerging Health Technologies Completed EH0110-000
Autologous Hematopoietic Stem Cell Transplant for People With Multiple Sclerosis
HTERP Guidance Statement – AHSCT for treatment of Multiple SclerosisHorizon Scan - Bulletin
 Optimal Use Complete EH0093 / OP0551
Trace Amine-Associated Receptor 1 Agonists for Schizophrenia
Trace Amine-Associated Receptor 1 Agonists for Schizophrenia
 Emerging Health Technologies Completed EH0105-000
Self-Collection of Nose and Throat Swab Samples for SARS-CoV-2 Antigen Testing
Self-Collection of Nose and Throat Swab Samples for SARS-CoV-2 Antigen Testing
 Emerging Health Technologies Completed EH0109-000
An Overview of Continuous Learning Artificial Intelligence-Enabled Medical Devices
An Overview of Continuous Learning Artificial Intelligence-Enabled Medical Devi…
 Emerging Health Technologies Completed EH0102-000
An Overview of New and Emerging Technologies for Early Diagnosis of Alzheimer Disease
An Overview of New and Emerging Technologies for Early Diagnosis of Alzheimer D…
 Emerging Health Technologies Completed EH0103-000
Tirzepatide for Type 2 diabetes mellitus
Tirzepatide for Type 2 diabetes mellitus
Emerging Health Technologies Completed EH0104-000
Emerging Multi-Cancer Early Detection Technologies
Emerging Multi-Cancer Early Detection Technologies
 Health Technology Update Completed EN0037-000
Electrospun Healing Fibres for the Management of Burns and Wounds
Electrospun Healing Fibres for the Management of Burns and Wounds
 Health Technology Update Completed EN0033-000

Projects in Progress

Last Updated
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Title Description Files Last Updated Project Line Project Sub Line Project Number
Formulary Management of Targeted Immune Modulators for Ulcerative Colitis
Health Technology Review Technology Review HD0010-000
Criteria for conducting Environmental Assessments in CADTH HTAs
Health Technology Review MG0017-000

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Title Description Files Last Updated Project Line Project Sub Line Status Project Number
semaglutide
Patient and Clinician Group input
 Reimbursement Review Active SR0841-000
durvalumab, tremelimumab
Patient and Clinician Group input
 Reimbursement Review Active PC0390-000
isatuximab
Patient and Clinician Group input
 Reimbursement Review Active PC0378-000
durvalumab
Patient and Clinician Group input
 Reimbursement Review Active PC0389-000
durvalumab, carboplatin, paclitaxel
Draft Recommendation and ReasonsPatient and Clinician Group input
 Reimbursement Review Active PC0366-000
teprotumumab
Patient and Clinician Group Input
 Reimbursement Review Withdrawn SR0853-001
ferric carboxymaltose
Draft Recommendation and ReasonsPatient and Clinician Group input
 Reimbursement Review Active SR0852-000
trofinetide
Draft RecommendationPatient and Clinician Group Input
 Reimbursement Review Active SR0829-000
asciminib
Patient and Clinician Group input
 Reimbursement Review Active PC0418-000
pembrolizumab
Patient and Clinician Group input
 Reimbursement Review Active PC0411-000
pembrolizumab
Patient and Clinician Group Input
 Reimbursement Review Active PC0410-000
asciminib
Patient and Clinician Group input
 Reimbursement Review Active PC0405-000
tofersen
Patient and Clinician Group Input
 Reimbursement Review Active SR0883-000
teprotumumab
Patient and Clinician Group Input
 Reimbursement Review Active SR0853-000
pegunigalsidase alfa
Patient and Clinician Group Input
 Reimbursement Review Active SR0872-000
talazoparib
Patient and Clinician Group Input
 Reimbursement Review Active PC0417-000
pembrolizumab
Patient and Clinician Group Input
 Reimbursement Review Active PC0383-000
pemigatinib
Draft Recommendation and ReasonsPatient and Clinician Group input
 Reimbursement Review Active PC0391-000
daratumumab
Draft Recommendations & ReasonsPatient and Clinician Group input
 Reimbursement Review Active PC0388-000
trastuzumab deruxtecan
Recommendation and Reason Patient and Clinician Group Input
 Reimbursement Review Active PC0367-000
blinatumomab
Draft Recommendations & ReasonsPatient and Clinician Group input
 Reimbursement Review Active PC0365-000
acalabrutinib
Patient and Clinician Group input
 Reimbursement Review Active PC0413-000
glofitamab
Patient and Clinician Group Input
 Reimbursement Review Active PC0406-000
efgartigimod alfa
Reimbursement Review Pending SR0894-000
nivolumab and ipilimumab
Patient and Clinician Group input
 Reimbursement Review Active PC0396-000

Provisional Funding Algorithm

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Title Tumour Type Therapeutic Area Files Project Number Project Status Final Recommendation/Report
Metastatic Urothelial Carcinom... Genitourinary Metastatic Urothelial Carcinoma
Final Report
 PH0008-000 Complete
Renal Cell Carcinoma Genitourinary Renal Cell Carcinoma
Final Report
 PH0019-000 Complete
Metastatic Urothelial Carcinom... Genitourinary Metastatic Urothelial Carcinoma
Final Report
 PH0017-000 Complete
Endometrial cancer Genitourinary Endometrial cancer
PH0066-000 Merged
Prostate cancer Genitourinary Prostate cancer
Proposed Scope
 PH0073-000 Open for Input
Urothelial carcinoma Genitourinary Urothelial carcinoma
Final Report
 PH0070-000 Complete
Renal cell carcinoma Genitourinary Renal cell carcinoma
Scoping Document
 PH0075-000 Open for Input
Endometrial Cancer Gynecology Endometrial Cancer
Final Report
 PH0045-000 Complete
Endometrial cancer Gynecology Endometrial cancer
Scoping DocumentScoping Document for PH0066-000
 PH0076-000 Active
Chronic Lymphocytic Leukemia Leukemia Chronic Lymphocytic Leukemia
Final Report
 PH0035-000 Complete
Adult B-Cell Precursor Acute L... Leukemia Adult B-Cell Precursor Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative and Positive
Final Report
 PH0030-000 Complete
Acute Myeloid Leukemia Leukemia Acute Myeloid Leukemia
Proposed Scope
 PH0082-000 In Progress
Adult B-Cell Precursor Acute L... Leukemia B-Cell Precursor Acute Lymphoblastic Leukemia
Final Report
 PH0002-000 Complete
Chronic Lymphocytic Leukemia Leukemia B-Cell Precursor Acute Lymphoblastic Leukemia
Final Report
 PH0004-000 Completed
Large B cell lymphoma Leukemia Large B cell lymphoma/ Lymphome B à grandes cellules
Final Report
 PH0064-000 Complete
Chronic lymphocytic leukemia (... Leukemia Chronic lymphocytic leukemia (CLL)
Final Report
 PH0063-000 Complete
Philadelphia negative acute ly... Leukemia Philadelphia negative acute lymphoblastic leukemia
Proposed Scope
PH0067-000 Active
Chronic Lymphocytic Leukemia Leukemia Chronic Lymphocytic Leukemia
Final Report
 PH0038-000 Complete
Non-Small Cell Lung Cancer wit... Lung Non-Small Cell Lung Cancer without actionable oncogenic alterations
Final Report
 PH0029-000 Complete
Non-small cell lung cancer (NS... Lung Non-small cell lung cancer (NSCLC) with activating epidermal growth factor receptor (EGFR) mutation
Final Report
 PH0054-000 Complete
Anaplastic Lymphoma Kinase (AL... Lung Anaplastic Lymphoma Kinase (ALK) -Positive Non-small Cell Lung Cancer (NSCLC)
Final Report
 PH0058-000 Complete
Non Small Cell Lung Cancer Lung Non Small Cell Lung Cancer
Proposed Scope
PH0085-000 Open for Input
Non-small Cell Lung Cancer Lung Non-small Cell Lung Cancer
PH0081-000 Merged
NSCLC without actionable oncog... Lung NSCLC without actionable oncogenic alteration
Final Report
 PH0046-000 Complete
Anaplastic Lymphoma Kinase Pos... Lung ALK-positive Locally Advanced or Metastatic Non-small Cell Lung Cancer
Final Report
 PH0009-000 Complete