This review examined the cost-effectiveness of an RSVpreF maternal vaccine administered during pregnancy for the prevention of respiratory syncytial virus outcomes in infants and in people who are pregnant.
Telephone triage programs provide timely access to trained health care professionals who can assess a patient’s symptoms over the phone and provide self-care advice or referral to an appropriate level of care. Some programs may also offer other services, such as direct access to allied health professionals or medical appointment booking. This environmental scan aims to describe telephone triage programs in Canada (e.g., provincial and territorial 811 programs), including what services they provide, who administers the programs, and how much they cost.
We did not find any evidence regarding the clinical effectiveness and safety of alternative treatments to IV Immunoglobulin (IVIg) compared to IVIg or placebo for multifocal motor neuropathy that met our inclusion criteria for this review.
We did not find any evidence-based guidelines regarding the use of alternative treatments to IVIg for multifocal motor neuropathy that met the criteria for this review.
Occupational therapy interventions may be effective for reducing symptoms of depression and anxiety and improving function and participation with the interventions in adult patients diagnosed with depression and/or anxiety.
In patients with schizophrenia, occupational therapy interventions may improve social functioning, cognitive performance, executive function, and motivation; and reduce the duration and rate of rehospitalization.
We did not find any evidence regarding the clinical effectiveness of occupational therapy for the treatment of bipolar disorders, obsessive-compulsive disorder, and post-traumatic stress disorder that met the inclusion criteria for our review.
We did not find any evidence meeting our inclusion criteria about the cost-effectiveness of occupational therapy for the treatment of mental health conditions, as well as the clinical effectiveness and cost-effectiveness of occupational therapy for the treatment of substance use disorders.
The objective of this observational study is to determine if the safety profile of niraparib in real-world patient populations differs from the clinical trial findings.
The need to monitor and manage adverse events means that patients must visit their health care providers more frequently. Real-world evidence may assist decision-making by supplementing the clinical trial data.
The drug utilization study explored the characteristics of patients with chronic idiopathic urticaria (CIU) who were administered omalizumab, as well as the use of omalizumab for longer than 24 weeks in 4 Canadian provinces.
The objective of this systematic review is to determine the efficacy, effectiveness, and safety of omalizumab administered for 24 weeks or longer in patients with chronic idiopathic urticaria (CIU). The review will also identify the characteristics of patients who use omalizumab for longer than 24 weeks.
In the real-world setting, omalizumab is seeing continued, longer-term use. The evidence will help inform the appropriateness of using long-term omalizumab in patients with CIU.
Several regulatory agencies have implemented processes to facilitate timely access for patients with high unmet medical needs to innovative therapies that may have important uncertainties in the evidence base at the time of initial assessment, and would typically require additional evidence generation. Many health technology assessment (HTA) agencies have adapted their processes to include time-limited recommendations (TLRs) that allow patients’ access to medications while additional data are collected to verify the therapy’s clinical and economic benefits.