faricimab

Details

Key Milestones2

Call for patient/clinician input openDecember 23, 2021
Call for patient/clinician input closedFebruary 18, 2022
Clarification:

- Patient input submission received from Fighting Blindness Canada, The Canadian Council of the Blind, CNIB, Vision Loss Rehabilitation Canada

Submission receivedJanuary 31, 2022
Submission acceptedFebruary 14, 2022
Review initiatedFebruary 17, 2022
Draft Canada's Drug Agency review report(s) provided to sponsor for commentMay 04, 2022
Deadline for sponsors commentsMay 13, 2022
Canada's Drug Agency review report(s) and responses to comments provided to sponsorJune 10, 2022
Expert committee meeting (initial)June 22, 2022
Draft recommendation issued to sponsorJuly 05, 2022
Draft recommendation posted for stakeholder feedbackJuly 14, 2022
End of feedback periodJuly 28, 2022
Final recommendation issued to sponsor and drug plansAugust 12, 2022
Final recommendation postedAugust 30, 2022
Deadline for sponsor to submit redaction requests on draft Canada's Drug Agency review report(s)August 26, 2022
Canada's Drug Agency review report(s) postedNovember 16, 2022

Homelike Models of Long-Term Care: A 2021 Update

Details

Question(s)

  1. What is the clinical effectiveness of homelike models of care (e.g., Eden Alternative and Greenhouse Concepts of Care) for residents of long-term care facilities?
  2. What is the cost-effectiveness of homelike models of care for residents of long-term care facilities?
  3. What are the evidence-based guidelines for homelike models of care for residents of long-term care facilities?

Key Message

Among residents with dementia, positive effects of small-scale homelike models of care on social interaction were observed in 1 non-randomized study, whereas the evidence from relevant primary studies captured in 1 systematic review was mixed. Residents with dementia living in small-scale homelike care facility compared with a traditional nursing home may spend more time in a positive mood or engagement, based on findings from 1 non-randomized study. Evidence captured in 1 systematic review suggested lower use of restraints and psychotropic drugs in small-scale homelike settings compared with traditional nursing homes; however, a non-randomized study published in 2020 found no differences in psychotropic drug use. Associations between homelike models of care and safety outcomes (e.g., COVID-19 infection, fall injuries) suggested a benefit of small-scale homelike long-term care settings over traditional large-scale settings.

The Small House Model for Long-Term Care

Details

Informed by literature, the key objectives of this Environmental Scan are to:

ospemifene

Details

Key Milestones2

Call for patient/clinician input open21-Sep-21
Call for patient/clinician input closed12-Nov-21
Clarification:

- Patient input submission received from the Women's Health Coalition of Alberta Society

Submission received26-Oct-21
Submission accepted09-Nov-21
Review initiated10-Nov-21
Draft Canada's Drug Agency review report(s) provided to sponsor for comment01-Feb-22
Deadline for sponsors comments10-Feb-22
Canada's Drug Agency review report(s) and responses to comments provided to sponsor11-Mar-22
Expert committee meeting (initial)23-Mar-22
Draft recommendation issued to sponsor06-Apr-22
Draft recommendation posted for stakeholder feedback14-Apr-22
End of feedback period29-Apr-22
Final recommendation issued to sponsor and drug plans13-May-22
Final recommendation posted01-Jun-22
Deadline for sponsor to submit redaction requests on draft Canada's Drug Agency review report(s)02-Jun-22
Canada's Drug Agency review report(s) posted11-Aug-22

Hip Protectors for Community-Dwelling Older Adults

Details

Question(s)

  1. What is the clinical effectiveness of hip protectors in preventing fall-related injuries among community-dwelling older adults?
  2. What are the evidence-based guidelines regarding the use of hip protectors in preventing fall-related injuries among community-dwelling older adults?

Key Message

In community-dwelling older adults who wore hip protectors there was no difference in the risk of hip fractures or pelvic fractures, compared to those who did not wear hip protectors.

Three guidelines were identified that include recommendations around the use of hip protectors in older adults. One guideline suggests that hip protectors should be considered in adults at risk for falls and hip fracture. One guideline conditionally recommends hip protectors for frail older adults in the appropriate environment. One guideline suggests that hip protectors should not be considered in older adults in community settings.

Neuromodulation Technologies for the Treatment of Alzheimer Disease

Details

There are not very many effective treatment options for Alzheimer disease and most of the options have side effects for many people, and temporarily reduce symptoms rather than delay disease progression. Effective treatments with minimal side effects that prevent and reduce the severity of Alzheimer disease are needed.

Vitamin D Supplementation for the Prevention and/or Treatment of Cardiovascular Disease, Cancer, and Other Conditions in Residents of Long-Term Care Facilities

Details

Question(s)

  1. What is the clinical effectiveness of vitamin D supplementation for the prevention and/or treatment of cardiovascular disease, cancer, and other conditions in elderly patients residing in long-term care facilities?
  2. What are the evidence-based guidelines regarding vitamin D supplementation for the prevention and/or treatment of cardiovascular disease, cancer, and other conditions in elderly patients residing in long-term care facilities?

Key Message

The results of 1 systematic review suggest that supplementation with vitamin D may provide some benefit for cancer-related mortality in older adults. It is unclear whether there is a benefit of vitamin D supplementation for all-cause mortality; however, no benefit was found for cardiovascular disease mortality, cardiovascular disease events, or cancer incidence.

There is limited and mixed evidence on the effectiveness of vitamin D supplementation for dementia and mild cognitive impairment in older adults.

The results of 1 systematic review suggest that vitamin D supplementation may provide protection against acute respiratory infections in the overall population; however, this result was not significant in the subgroup of patients older than 65 years.

No evidence-based guidelines were identified regarding vitamin D supplementation for the prevention and/or treatment of cardiovascular disease, cancer, and other conditions in elderly patients residing in long-term care facilities.

Vitamin D Supplementation for the Prevention of Falls and Fractures in Residents of Long-Term Care Facilities: A 2021 Update

Details

Question(s)

1. What is the clinical effectiveness of vitamin D supplementation for the prevention of falls and fractures in elderly patients residing in long-term care facilities? 2. What is the cost-effectiveness of vitamin D supplementation for the prevention of falls and fractures in elderly patients residing in long-term care facilities? 3. What are the evidence-based guidelines regarding vitamin D supplementation for the prevention of falls and fractures in elderly patients residing in long-term care facilities?

Key Message

The relevant publications identified comprised 1 overview of systematic reviews and 2 systematic reviews. There is a suggestion that for seniors living in long-term care facilities, compared to control, vitamin D supplementation, with or without calcium, may reduce the rate of falls and fractures; however, the reductions were not always statistically significant.There were no statistically significant differences in the number of seniors who fell with vitamin D supplementation, with or without calcium, compared with control groups. Findings need to be interpreted with caution, considering the limitations such as primary studies of variable quality (critically low to moderate) and lack of clarity with respect to the type of long-term care setting.No cost-effectiveness studies regarding vitamin D supplementation for the prevention of falls and fractures in elderly patients residing in long-term care facilities were identified. No evidence-based guidelines regarding vitamin D supplementation for the prevention of falls and fractures in elderly patients residing in long-term care facilities were identified.

Urethral Inserts for the Management of Adult Male Urinary Incontinence

Details

Question(s)

  1. What is the clinical effectiveness of male urethral inserts for the management of male urinary incontinence?
  2. What is the cost-effectiveness of male urethral inserts for the management of male urinary incontinence?

Key Message

No evidence was identified regarding the clinical effectiveness of male urethral inserts for the management of male urinary incontinence. No evidence was identified regarding the cost-effectiveness of male urethral inserts for the management of male urinary incontinence.