blinatumomab

Details

Key Milestones2
Call for patient/clinician input open06-Sep-24
Call for patient/clinician input closed25-Nov-24
Submission received18-Oct-24
Submission accepted01-Nov-24
Review initiated04-Nov-24
Draft CADTH review report(s) provided to sponsor for comment31-Jan-25
Deadline for sponsors comments07-Feb-25
CDA-AMC review report(s) and responses to comments provided to sponsor28-Feb-25
Expert committee meeting (initial)12-Mar-25
Draft recommendation issued to sponsor25-Mar-25
Draft recommendation posted for stakeholder feedback03-Apr-25
End of feedback period17-Apr-25
Final recommendation issued to sponsor and drug plans01-May-25
Final recommendation posted-
Deadline for sponsor to submit redaction requests on draft CADTH review report(s)15-May-25
CDA-AMC review report(s) posted-

guselkumab

Details

Key Milestones2
Call for patient/clinician input openSeptember 05, 2024
Call for patient/clinician input closedOctober 28, 2024
Submission receivedOctober 21, 2024
Submission acceptedNovember 04, 2024
Review initiatedNovember 05, 2024
Draft CADTH review report(s) provided to sponsor for commentFebruary 07, 2025
Deadline for sponsors commentsFebruary 19, 2025
CDA-AMC review report(s) and responses to comments provided to sponsorMarch 13, 2025
Expert committee meeting (initial)March 26, 2025
Draft recommendation issued to sponsor-
Clarification:

- CDEC recommendation held pending receipt of NOC and evaluation of the finalized submission requirements.

Draft recommendation posted for stakeholder feedback-
End of feedback period-

trametinib

Details

Key Milestones2
Submission received06-Sep-24
Review initiated09-Sep-24
Expert committee meeting (initial)30-Jan-25
Draft recommendation posted for stakeholder feedback20-Feb-25
End of feedback period06-Mar-25
Final recommendation posted01-Apr-25
CDA-AMC review report(s) posted13-Mar-25

ruxolitinib

Details

Key Milestones2
Call for patient/clinician input open05-Sep-24
Call for patient/clinician input closed28-Oct-24
Submission received17-Oct-24
Submission accepted31-Oct-24
Review initiated01-Nov-24
Draft CADTH review report(s) provided to sponsor for comment31-Jan-25
Deadline for sponsors comments11-Feb-25
CDA-AMC review report(s) and responses to comments provided to sponsor13-Mar-25
Expert committee meeting (initial)26-Mar-25
Draft recommendation issued to sponsor08-Apr-25
Draft recommendation posted for stakeholder feedback17-Apr-25
End of feedback period05-May-25

durvalumab, tremelimumab

Details

Key Milestones2
Call for patient/clinician input open05-Sep-24
Call for patient/clinician input closed28-Oct-24
Submission received17-Oct-24
Submission accepted31-Oct-24
Review initiated01-Nov-24
Draft CADTH review report(s) provided to sponsor for comment23-Jan-25
Deadline for sponsors comments04-Feb-25
CDA-AMC review report(s) and responses to comments provided to sponsor28-Feb-25
Expert committee meeting (initial)12-Mar-25
Draft recommendation issued to sponsor24-Apr-25
Draft recommendation posted for stakeholder feedback01-May-25
End of feedback period15-May-25

durvalumab, carboplatin, paclitaxel

Details

Key Milestones2
Call for patient/clinician input open04-Sep-24
Call for patient/clinician input closed28-Oct-24
Submission received16-Oct-24
Submission accepted30-Oct-24
Review initiated31-Oct-24
Draft CADTH review report(s) provided to sponsor for comment22-Jan-25
Deadline for sponsors comments03-Feb-25
CDA-AMC review report(s) and responses to comments provided to sponsor28-Feb-25
Expert committee meeting (initial)12-Mar-25
Draft recommendation issued to sponsor26-Mar-25
Draft recommendation posted for stakeholder feedback03-Apr-25
End of feedback period17-Apr-25
Clarification:

- Reconsideration: major revisions requested by sponsor

- Request for reconsideration not accepted

.
Final recommendation issued to sponsor and drug plans05-May-25
Final recommendation posted-
Deadline for sponsor to submit redaction requests on draft CADTH review report(s)20-May-25
CDA-AMC review report(s) posted-

durvalumab, olaparib, carboplatin, paclitaxel

Details

Key Milestones2
Call for patient/clinician input openSeptember 04, 2024
Call for patient/clinician input closedOctober 28, 2024
Submission receivedOctober 16, 2024
Submission acceptedOctober 30, 2024
Review initiatedOctober 31, 2024
Clarification:

- Submission temporarily suspended

- Voluntarily withdrawn by the sponsor on 29 Jan 2025

Cladribine and Natalizumab for Relapsing-Remitting Multiple Sclerosis

Details

Multiple sclerosis (MS) is a chronic autoimmune disease with the following clinical manifestations: demyelination, inflammation, neuronal loss, and gliosis (scarring). Relapsing-remitting multiple sclerosis (RRMS) is the most common type of the disease, with a subgroup of patients who have a more aggressive disease course — manifesting with a rapid accumulation of physical or cognitive deficits — which is referred to as highly active RR  MS.

Key Milestones
Call for patient/clinician/industry input open29-Aug-24
Call for patient/clinician/industry input closed13-Sep-24
Review initiated29-Aug-24
Expert committee meeting (initial)30-Jan-25
Draft recommendation posted for stakeholder feedback20-Feb-25
Draft report posted for stakeholder feedback20-Feb-25
End of feedback period06-Mar-25
Final recommendation posted28-Mar-25
Review report(s) posted  23-Apr-25

HR positive, HER2 negative breast cancer