Key Message

For older adults with incontinence in a personal care home setting, using a bladder scanner to assist traditional urinary incontinence care may reduce the amount of daytime urine loss and use of incontinence pads without increasing caregivers’ care burden.

Adding a bladder scanner to urinary incontinence care may not impact patient quality of life, mental state, depression, physical function, and level of motivation.

These findings were based on 2 studies, 1 of which lacked a control group and did not directly measure the effect of adding a bladder scanner to urinary incontinence care on patients’ urine loss. This may limit our confidence in the findings.

We did not find any studies that reported on the effect of using bladder scanners in the personal care setting on rates of catheterization, emergency department visits, urinary tract infections, or other harms. We also did not identify any cost-effectiveness studies or evidence-based guidelines that met inclusion criteria for this report.

Key Message

Both included economic evaluation studies (1 from Iran and 1 from Australia) found that tenecteplase was the dominant treatment strategy (i.e., lower costs and higher benefit) compared with alteplase over a lifetime horizon.

Key Message

This review identified limited evidence about the clinical effectiveness of dental bridges for partial tooth loss in adults. The identified studies had several limitations, including limited comparative data and concerns related to a lack of dental bridge specificity. Therefore, the findings related to effectiveness are uncertain.

In adults with partial tooth loss who have dental bridges supported by natural teeth, there may be minimal rates of dental bridge failure, high rates of dental bridge survival, and few complications.

Limited evidence from 1 study with a small number of patients that directly compared all-ceramic dental bridges with metal-ceramic dental bridges reported no failures in either group but suggested that patients with all-ceramic dental bridges may have more complications and changes in patient satisfaction, but the findings were uncertain.

One patient with lived experience shared clinical information related to the use of a dental bridge and reported that the dental bridge helped facilitate eating but they experienced issues with chipping which negatively affected function and satisfaction with the appearance of the bridge, which also had financial implications for repair and replacement of the damaged bridge. None of the studies in this report included direct measures related to the patient-identified outcomes, specifically financial implications.

We did not find any studies that compared dental bridges to partial dentures or different designs of dental bridges, nor did we find any studies on the cost-effectiveness of dental bridges that met the criteria for this review.

We did not find any evidence-based guidelines on the use of dental bridges for adults with partial tooth loss that met the criteria for this review.

Key Message

Sotrovimab may not have clinical effectiveness in treating Omicron subvariant BA.2. This finding generally aligns with the Health Canada and WHO recommendations and the findings of previously published in vitro studies against the use of sotrovimab for Omicron subvariants, except for BA.1. Given the limited number and observational, nonrandomized design of the included studies, and the absence of evidence on the clinical effectiveness of sotrovimab for outpatients with confirmed COVID-19 Omicron subvariants BA.3 to BA.5, it was difficult to draw a firm conclusion about the clinical effectiveness of sotrovimab for Omicron subvariants.

Key Message

No evidence was identified regarding the diagnostic test accuracy or clinical utility of copper and ceruloplasmin tests compared to other tests or criteria to detect Wilson disease and Menkes disease in children with global development delay and intellectual disability that met the criteria for this review.

No evidence-based guidelines were found on the use of copper and ceruloplasmin tests for children with global developmental delay and intellectual disability that met the criteria for this review.